Dataset Information
An integrative analysis of genetic factors reveals dysregulation of cytokines, immune signaling, and T cell activity as the underlying immune mechanisms in autoimmune immune thrombocytopenia.
Ontology highlight
ABSTRACT:
SUBMITTER: Patidar P
PROVIDER: S-EPMC12918271 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
An integrative analysis of genetic factors reveals dysregulation of cytokines, immune signaling, and T cell activity as the underlying immune mechanisms in autoimmune immune thrombocytopenia.
Thrombosis journal 20260127 1
BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated platelet destruction, leading to an abnormally reduced platelet count. While numerous susceptibility genomic loci have been identified, the genetic mechanisms and pathways driving ITP remain poorly understood. This limits treatment options to broad immunosuppressants that increase patient vulnerability. OBJECTIVE: This study aims to uncover the functional and biological significance of ITP-associ ...[more]
