Circularization of 23S rRNA but not 16S rRNA within archaeal ribosomes.

ABSTRACT:

Background

Processing of archaeal 16S and 23S rRNAs is believed to involve excision of individual rRNAs from polycistronic precursors, circularization of excised rRNAs, and re-linearization before the incorporation into ribosomes. However, all the knowledge is derived from several isolated species, leaving open the possibility that different processes may occur in other archaeal groups.

Results

Here, we investigate rRNAs from diverse and mostly uncultivated archaea. Sequencing of total cellular RNA from eight phylum-level lineages indicates that archaeal circular 23S rRNA transcript abundances vastly exceed those of linear counterparts, and linear versions are often undetectable. As the majority of rRNAs derive from mature ribosomes, the data suggest that ribosomes contain c

SUBMITTER: Shi LD 

PROVIDER: S-EPMC12918454 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature