Association of HDL subclass components with all-cause and cardiovascular mortality: a prospective cohort study based on the ChinaHEART project.

ABSTRACT:

Background

While the U-shaped association between high-density lipoprotein cholesterol (HDL-C) levels and the risk of all-cause and cardiovascular mortality is well-established, the underlying contributions of HDL subclasses remain poorly understood. This study aimed to comprehensively analyze the variations of HDL subclass components across different HDL-C levels and assess their associations with the risk of all-cause and cardiovascular mortality.

Methods

This study enrolled 1,585 participants aged 35-75 years from China Health Evaluation And risk Reduction through nationwide Teamwork (ChinaHEART) (2014-2023). Lipoprotein parameters were measured by nuclear magnetic resonance, with a focus on triglycerides (TG), cholesterol (CH), free cholesterol (FC), phospholipids (PL),

SUBMITTER: Liu X 

PROVIDER: S-EPMC12918455 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature