Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model.

ABSTRACT:

Background

Transcranial magnetic stimulation (TMS) is a widely used non-invasive brain stimulation technique, but the neural circuits activated by TMS remain poorly understood. Previous modeling approaches have been limited to either simplified point-neuron networks or isolated single-cell models that lack synaptic connectivity.

Objective

To develop and validate a multiscale cortical circuit model that integrates morphologically-realistic neurons with accurate TMS-induced electric field distributions and to investigate mechanisms underlying cortical responses to stimulation.

Methods

We constructed a network model of a cortical column comprising 10,000 neurons across layers 2/3, 5, and 6 with over 10 million synaptic connections. The model incorporated thalamic and non

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12918517 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature