Comparison of different heparin locking frequencies in patients with unremoved catheters after continuous renal replacement therapy in the intensive care unit: a prospective, open-label, randomized controlled trial protocol from China.

ABSTRACT:

Background

To investigate the impact of different heparin locking frequencies on the incidence of catheter dysfunction among patients with unremoved dialysis catheters after continuous renal replacement therapy (CRRT) in the Intensive Care Unit (ICU) of Wuhan, China. The study aims to identify a relatively low-risk locking frequency for catheter dysfunction, evaluate its effects on maintaining catheter patency and preventing catheter-related bloodstream infections (CRBSI), and determine the optimal locking strategy that balances infection risk and catheter functionality. And conduct a cost-effectiveness analysis to assess the economic value of different locking frequencies, including total medical costs.

Methods

This is a prospective, open-label, parallel-group, single-cente

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12918543 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature