Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.

ABSTRACT:

Background

Postmenopausal women are at increased risk of developing cardiovascular, muscular, and metabolic dysfunction due to hormonal changes associated with aging. Citrulline, a non-essential amino acid and precursor to nitric oxide, has gained interest as a potential dietary supplement for improving vascular health, muscle function, and metabolic parameters in this population.

Objective

This systematic review aims to evaluate the effects of citrulline supplementation, administered directly or via watermelon products, on cardiovascular, muscular, and metabolic outcomes in postmenopausal women.

Methods

A comprehensive literature search was conducted using PubMed, Web of Science, and Scopus databases to identify randomized controlled trials (RCTs) investigating citru

SUBMITTER: Bahari H 

PROVIDER: S-EPMC12918617 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature