The <i>Pseudomonas aeruginosa</i> PrrF sRNAs and PqsA promote biofilm formation at body temperature.

ABSTRACT: Pseudomonas aeruginosa is a gram-negative opportunistic pathogen that causes both acute and chronic infections in vulnerable populations. Treatment of P. aeruginosa infections is increasingly challenging due to multi-drug resistance, and biofilm formation during infection further increases antibiotic tolerance. Iron, which is sequestered by the host innate immune system, is also a key nutrient that is required for P. aeruginosa biofilm formation. The iron-responsive PrrF small regulatory RNAs (sRNAs) are key to P. aeruginosa's iron starvation response, promote the production of the Pseudomonas quinolone signal (PQS) quorum sensing molecule, and are required for virulence in murine lung infection. Prior work showed that the PrrF sRNAs are dispensable for b

SUBMITTER: Chourashi R 

PROVIDER: S-EPMC12918728 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature