Inhibition of carboxypeptidase b1 from Anopheles stephensi by the potato carboxypeptidase inhibitor: a foundational step toward paratransgenesis-based malaria control.

ABSTRACT: Vector-borne diseases such as malaria are a threat to global public health and the economy. These diseases were proposed to be managed and controlled by new preventive strategies such as paratransgenesis. This is an innovative technique that makes use of symbiotic microorganisms to influence vector or targeted pathogens. The performed studies on Anopheles stephensi and Anopheles gambiae demonstrated that the carboxypeptidase-B1 enzyme plays a vital role in the sexual development of the Plasmodium parasite in the mosquito midgut by its enzymatic activity. Therefore, inhibiting its enzymatic activity could be a target for preventing approaches. Potato Carboxypeptidase Inhibitor (PCI) has desirable characteristics that make it a promising effector molecule for paratransgenesis. In this study,

SUBMITTER: Monshizadeh Z 

PROVIDER: S-EPMC12918738 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature