Exosomes displaying native EGF enhance doxorubicin's therapeutic efficacy and reduce cardiotoxicity.

ABSTRACT:

Background

Doxorubicin (DOX) is one of the most potent chemotherapeutic agents for cancer treatment. However, its cumulative and often irreversible, life-threatening cardiotoxicity significantly limits its clinical applications. While strategies like dose reduction, iron chelation, and liposome encapsulation have aided in mitigating cardiotoxicity to certain extent, they are associated with decreased therapeutic efficacy and potential cancer relapse, the risk of developing secondary malignancy, and the incidence of the Hand-foot syndrome. Exosomes (Exo) are naturally occurring nanoparticles that can be engineered to display targeting moieties on their surface, thereby enhancing drug delivery efficacy. We aimed to develop an exosomal DOX formulation targeting broad epidermal growth

SUBMITTER: Mao L 

PROVIDER: S-EPMC12918744 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature