Accelerated DMN-Targeted cTBS Improves Processing Speed Deficits in Schizophrenia.

ABSTRACT:

Objective

Cognitive deficits are a leading cause of disability in schizophrenia and are linked to poor functional outcomes. There are no first line treatments for these deficits, and their neural basis is poorly understood. While schizophrenia is associated with widespread cognitive deficits, information processing speed is most profoundly impaired. Processing speed deficits have been associated with hyperconnectivity in the Default Mode Network (DMN). We therefore tested if modulating DMN connectivity with single or multiple sessions of transcranial magnetic stimulation (TMS) applied to an individualized DMN target would affect processing speed.

Methods

In the first study, 10 individuals with schizophrenia received single TMS sessions and underwent resting-state neuroimagin

SUBMITTER: Connolly JG 

PROVIDER: S-EPMC12919089 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature