An Fc receptor and IgA functional signature identifies TB disease in children living with HIV.

ABSTRACT:

Background

Tuberculosis (TB) is a leading cause of morbidity and mortality among children living with HIV (CLHIV). Poor diagnostic performance is a significant contributor. Serological assays that determine levels of Mycobacterium tuberculosis reactive antibodies inconsistently detect TB. However, antigen-specific antibody Fc receptor engagement and effector functions are promising biomarkers of TB disease.

Methods

This study evaluated serum from a well-characterized cohort of Kenyan CLHIV via two orthogonal approaches: 1) longitudinally following over the course of TB treatment and 2) assessing a cross-section with and without clinical TB disease. For each individual sample, 13 antibody functional properties against 8 Mtb and 4 non-Mtb microbial antigen

SUBMITTER: Kang YJ 

PROVIDER: S-EPMC12919122 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature