Predictive Value of Plasma P-tau217 and <i>APOE</i> Genotype for Preclinical Cognitive Decline in Alzheimer's Disease.

ABSTRACT:

Background

APOE -ρ.4 is the strongest genetic risk factor for Alzheimer's disease (AD), and plasma phosphorylated tau217 (P-tau217) is a highly sensitive and specific biomarker for AD pathology. Their combined utility to predict cognitive decline before onset of AD has not been systematically evaluated.

Methods

Using longitudinal data from multiple cohorts, we evaluated plasma P-tau217 as a predictor of when cognitive impairment occurs in AD. P-tau217 concentrations were analyzed as continuous and binary variables using cohort-specific biomarker positivity thresholds. Association of plasma P-tau217 with prevalent and incident cognitive impairment were assessed using logistic regression and Cox models, stratified by APOE genotype. Adjusted survival curves and re

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12919147 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature