Effects of dietary myo-inositol supplementation on the expression of fibroblast growth factor 23 (FGF23) and αKlotho in two commercial laying hen strains.

ABSTRACT: Phosphate homeostasis is controlled by fibroblast growth factor 23 (FGF23) produced by bone cells in mammals and primarily acting in the kidney. For its phosphaturic effect and for suppression of production of active vitamin D, it requires αKlotho as a co-receptor. FGF23 and αKlotho have emerged as disease biomarkers. Relatively little is known about their significance in laying hens that are in particular need of balanced mineral homeostasis for eggshell formation. Dietary myo-inositol (MI) and phosphate metabolism are interdependent, and this study aimed to explore FGF23 and αKlotho expression in two commercial hen strains fed different amounts of MI. Forty Lohmann Brown Classic (LB) and Lohmann LSL-Classic (LSL) 26-week-old hens received standard diets with 0, 1, 2, or 3 g supplemental

SUBMITTER: Meier L 

PROVIDER: S-EPMC12919247 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature