Protective effects of a multicomponent toxin binder and organic acid blend on feed efficiency, oxidative status, hepatic histology, and jejunal immune-antioxidant responses in broilers co-challenged with aflatoxin B₁ and Clostridium perfringens.

ABSTRACT: This study evaluated the effects of a multicomponent toxin binder (MTB) and an organic acid blend (OAB) on performance, immunity, oxidative status, liver histology, and jejunal inflammatory/antioxidant gene expression in broilers challenged with aflatoxin B₁ (AFB₁) and Clostridium perfringens. A total of 420 Ross 308 broilers were assigned to seven groups (6 replicates × 10 birds): Control (unchallenged), A (AFB₁), AM (AFB₁ + MTB), AMO (AFB₁ + MTB + OAB), AC (AFB₁+ C. perfringens), ACM (AFB₁ + C. perfringens + MTB), and ACMO (AFB₁ + C. perfringens + MTB+OAB). AFB₁ (500 ppb) was provided throughout days 0-42; C. perfringens (1 × 10⁸ CFU/mL) was administered on days 15-24. AFB₁ alone

SUBMITTER: Karimi Zandi M 

PROVIDER: S-EPMC12919270 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature