Multidrug-resistant colonization in decompensated cirrhosis outside the ICU predicts infection and poor outcomes.

ABSTRACT:

Background & aims

Infections caused by multidrug- (MDROs) or extensively drug- (XDROs) resistant organisms are an increasing global concern in cirrhosis. While MDRO colonization is a recognized risk factor for infection in critical care settings, evidence in ward-based patients with decompensated cirrhosis is limited. This study aimed to determine the prevalence, dynamics, and clinical impact of MDRO colonization outside the intensive care unit (ICU) and to identify predictors of colonization and infection.

Methods

We conducted a single-center prospective study (2017-2020) enrolling 408 patients with decompensated cirrhosis consecutively admitted to the ward (n = 272) or ICU (n = 136). Rectal and nasal swabs were obtained at admission and weekly for up to 12 months. Coloniza

SUBMITTER: Hernandez-Tejero M 

PROVIDER: S-EPMC12919291 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature