GO/MNPs-TEA-CuI in water: a green and efficient catalytic system for multicomponent preparation of highly substituted imidazoles and oxazoles.

ABSTRACT: A sustainable and highly efficient catalytic protocol has been developed employing graphene oxide-supported magnetic nanoparticles functionalized with triethanolamine and copper(I) iodide (GO/MNPs-TEA-CuI) for the synthesis of functionalized imidazole and oxazole derivatives. This magnetically recoverable catalyst promotes multicomponent coupling reactions between aryl aldehydes, aryl nitriles, and terminal alkynes in aqueous media under reflux conditions, emphasizing its environmentally benign nature. The system efficiently affords a broad scope of products in excellent yields (77%-99%) within short reaction times (15-80 min for imidazoles and 1-8 h for oxazoles). The catalyst exhibits outstanding activity, attributed to the synergistic interaction between the GO surface, magnetic core, a

SUBMITTER: Abu Shuheil M 

PROVIDER: S-EPMC12919339 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature