Regulation of Vascular Tone of Preglomerular Renal Vasculature by Caldesmon.

ABSTRACT:

Background

Caldesmon is an actomyosin-tropomyosin-binding protein with pleiotropic functions that generally acts as an inhibitor of actomyosin ATPase activity. This study aims to explore the role of caldesmon in regulation of preglomerular vascular tone.

Methods

Expression of caldesmon, myosin light chain, and α-smooth muscle actin was assessed by western blot of interlobar arteries (IAs) from young and old mice or human renal arteries from patients who underwent nephrectomy or tumor enucleation. IAs were obtained from wild-type or heterozygous mice, carrying a mutant allele that ablates both caldesmon isoforms (caldesmon^+/-). In IAs, the vasoreactivity to α₁-agonist phenylephrine, the soluble guanylate cyclase activator cinaciguat, and inhibitors of Rh

SUBMITTER: Pryymachuk G 

PROVIDER: S-EPMC12919474 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature