Association Between Ipsilateral Stroke and Nonstenotic (<50%) Carotid Disease: Secondary Analysis From the AcT Trial.

ABSTRACT:

Background

Symptomatic nonstenotic (<50% stenosis) carotid disease in the presence of high-risk plaque features is a potential cause of ischemic stroke. We assessed stroke risk associated with symptomatic nonstenotic carotid disease.

Methods

This cross-sectional secondary analysis of the AcT (Alteplase Compared to Tenecteplase) randomized controlled trial evaluated baseline computed tomography angiograms for degree of internal carotid artery stenosis, plaque features and the presence of intraluminal thrombi, webs, dissection, and rim sign. Stroke location was evaluated on 24-hour follow-up imaging. At a carotid level, mixed-effects logistic regression models adjusted for age and sex, with patient identity as a random effect, examined associations between "concordant stroke"

SUBMITTER: Ignacio KHD 

PROVIDER: S-EPMC12919477 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature