Effect of Mitochondria-Derived Methylmalonic Acid on Progress and Mortality Risk in US Adults With Cardiovascular-Kidney-Metabolic Syndrome.

ABSTRACT:

Background

Methylmalonic acid (MMA) is regarded a biomarker of aging, oxidative stress, and mitochondrial dysfunction, which are also pathophysiological mechanisms that underlying cardiovascular-kidney-metabolic (CKM) syndrome. Nevertheless, the relationship between MMA per se and CKM remains unclear.

Methods

This prospective cohort study was based on data from the National Health and Nutrition Examination Survey (1999-2018). Multinomial logistic regression was conducted to evaluate the relationship between MMA and CKM stages. Hazard ratios (HRs) and 96% CI for the association between MMA and mortality were calculated using the multivariable Cox regression model. The mediating role of MMA on the association between cardiometabolic biomarkers and mortality was estimating usin

SUBMITTER: Liu H 

PROVIDER: S-EPMC12919479 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature