Low Serum Lysophospholipids Predict Increased In-Hospital Mortality in Patients With Acute Heart Failure.

ABSTRACT:

Background

New biomarkers are needed to improve risk prediction in patients with acute heart failure. We aimed to identify serum lipids with prognostic value and clinical utility in patients hospitalized due to acute heart failure.

Methods

Targeted mass spectrometry-based lipidomics was performed on serum samples from 315 (discovery) and 139 (validation) patients prospectively enrolled in 2 observational acute heart failure studies. Prognostic lipids were identified by consolidating orthogonal partial least squares discriminant analysis, least absolute shrinkage and selection operator regression, and random forest (Boruta) results into a single ranking using TopKSignal.

Results

In the discovery cohort, lysophosphatidylethanolamine 20:4, lysophosphatidylcholine 20:4, l

SUBMITTER: Klobucar I 

PROVIDER: S-EPMC12919526 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature