Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing.

ABSTRACT: Mapping neural computation onto the functional microarchitecture of sensory circuits is essential for understanding how brain circuits transform input signals into coherent percepts. Many higher-order perceptual processes emerge in the cortex, yet relatively little is known about how specific connectivity motifs give rise to these computations. To address this challenge, we combined single-cell and population-level physiological recordings and perturbation methods to map a context-dependent cortical computation onto the synaptic microarchitecture of the mouse primary visual cortex (V1). We demonstrate a precise pattern of synaptic connectivity from cortical pyramidal cells (PCs) to somatostatin (SST) inhibitory interneurons that mediates context-driven figure/ground modulation in V1. Throu

SUBMITTER: Hendricks WD 

PROVIDER: S-EPMC12919646 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature