Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis.

ABSTRACT:

Objective

Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long-term benefits of HCQ on kidney function preservation is critical. Therefore, we analyzed data from our retrospective longitudinal inception LN cohort to examine the time-varying effects of HCQ on kidney function decline in LN.

Methods

We analyzed retrospective data from an incident biopsy-proven LN cohort. Creatinine values at LN diagnosis through the last follow-up were abstracted to find the estimated glomerular filtration rate (eGFR). Using HCQ exposure as a time-dependent covariate, we examined associations between HCQ expos

SUBMITTER: Garg S 

PROVIDER: S-EPMC12919701 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature