Multi-contrast X-ray microtomography of human lung specimens with an extended field-of-view.

ABSTRACT:

Background

Phase-based X-ray microtomography is a powerful technique capable of quantitative volumetric imaging of lung tissue in health and disease. The maximum sample size is however limited by the fixed sizes of detectors and optical elements. Thus while high-resolution imaging can offer valuable microscale insights, it can be difficult to interpret without the context of the surrounding tissue. We propose a multi-contrast and multi-scale approach, combined with an offset geometry to extend the field-of-view (FOV).

Purpose

FOV limitations make it a challenge to simultaneously achieve high spatial-resolution and image large samples. Our method doubles the possible FOV achievable for a given spatial-resolution, in a way compatible with multiple scales and imaging systems.

SUBMITTER: Allan H 

PROVIDER: S-EPMC12919702 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature