Sex-specific glomerular filtration rate changes in response to acute hemoglobin exposure.

ABSTRACT: Hemoglobin (Hb) toxicity is a known contributor to acute kidney injury (AKI), particularly under hemolytic conditions where cell-free Hb is present in circulation. When the endogenous Hb scavenger protein haptoglobin becomes saturated with cognate ligand Hb, excess unbound cell-free Hb extravasates into tissues, including the kidneys, leading to oxidative stress, inflammation, and impaired renal function. Although sex-based differences in AKI susceptibility have been observed, the protective role of hormones in modulating the severity of Hb-induced kidney injury remains unclear. In this study, we evaluated the impact of biological sex, specifically estrous cycle status, on renal responses to acute Hb exposure. Glomerular filtration rate (GFR) was measured noninvasively using the Medibeacon

SUBMITTER: Lucas D 

PROVIDER: S-EPMC12919708 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature