Unveiling the biochemical potential of Acacia jacquemontii as a therapeutic agent in parkinson's disease: A multi-model in Vitro, In Vivo, and In Silico Study.

ABSTRACT: Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by oxidative stress, inflammation, and the degeneration of dopaminergic neurons. Current treatments focus more on symptom management rather than disease prevention. Acacia jacquemontii, rich in antioxidants, may offer a novel therapeutic approach for PD. This study aims to investigate the phytochemical composition, antioxidant capacity, anti-Parkinsonian efficacy, and in-silico validation of Acacia jacquemontii methanol extract (AJME) using liquid chromatography-mass spectrometry (LC-MS). Secondary metabolites were identified, and total alkaloid, phenolic, and flavonoid contents were quantified. LC-MS was used for detailed compound profiling. Antioxidant activity was evaluated using the DPPH assay. In vivo tests on

SUBMITTER: Asghar A 

PROVIDER: S-EPMC12919844 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature