Gene and drug-mediated SERCA2a activation restores cardiac function and metabolic balance in diabetic mice.

ABSTRACT: Diabetic cardiomyopathy is a major complication of diabetes mellitus, characterised by impaired calcium homeostasis, insulin resistance, and metabolic dysregulation. Notably, the expression and activity of sarco/endoplasmic reticulum Ca²⁺-ATPase 2a (SERCA2a) are diminished in diabetic heart failure, contributing to both systolic and diastolic dysfunction. Although enhancing SERCA2a function has shown beneficial cardiac effects, the underlying metabolic mechanisms remain unclear. The objective of this study was to investigate the effect of pharmacological activation of SERCA2a in the diabetic heart. This study aimed to evaluate the impact of pharmacological activation of SERCA2a on cardiac function and metabolism in a diabetic context. Leptin-deficient (Ob/ob) diabetic mice were treated usi

SUBMITTER: Kang S 

PROVIDER: S-EPMC12919852 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature