Dupilumab treatment outcomes in bullous pemphigoid: a systematic review and single-arm meta-analysis.

ABSTRACT:

Background

Bullous pemphigoid (BP) is the most common autoimmune subepidermal bullous disease of the skin. Novel biologic agents represent a potential therapeutic option. We explore the use of dupilumab in the treatment of BP.

Methods

Relevant studies published up to Oct. 20th, 2025 were systematically searched using PubMed, Web of Science, Embase, and Cochrane Library. Proportion rates of complete response and disease control were analyzed to determine treatment effects. Data were quantitatively synthesized using a random-effects meta-analysis. Meanwhile, we also conducted statistics on adverse events.

Results

A total of 587 patients from 24 studies were included. Pooled analysis revealed a complete response rate of 68% (95% CI 60%∼78%) and disease control rate of 95

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12920225 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature