Distant metastasis risk and prognosis in elderly gastric cancer patients after neoadjuvant chemotherapy and surgery.

ABSTRACT:

Background

Gastric cancer imposes a heavy global health burden, and treatment evaluation in elderly patients is often more complex. Although NAC is standard for locally advanced gastric cancer (LAGC), benefits in the elderly are heterogeneous, postoperative distant metastasis (DM) is underexplored, and no nomogram specifically evaluates postoperative DM diagnosis and prognosis in elderly LAGC after NAC.

Methods

This study extracted data from patients over 70 years of age who were diagnosed with gastric adenocarcinoma and underwent neoadjuvant chemotherapy followed by curative gastrectomy between 2016 and 2022. Independent risk factors for postoperative distant metastasis following neoadjuvant chemotherapy were identified using univariate and multivariate logistic regression

SUBMITTER: Shang J 

PROVIDER: S-EPMC12920236 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature