Novel radiohybrid PET-Tracers for SST₂-targeted imaging of neuroendocrine tumors.

ABSTRACT:

Purpose

⁶⁸Ga- and ¹⁷⁷Lu-labeled theranostic companion tracers have become a mainstay in the clinical management of SST₂ overexpressing neuroendocrine tumors. Despite the excellent radionuclide characteristics of [¹⁸F]fluorine for PET imaging, ¹⁸F-labeled SST₂-targeted tracers remain underrepresented. Novel radiohybrid SST₂-tracers with DOTA as a bridging unit were designed, allowing radiolabeling with either ¹⁸F or ⁶⁸Ga.

Methods

Seven DOTA-TATE derivatives (rhTATE1/2: N-SiFAlin-N, N-Me₂-Gly-D-Dap/Lys(trans-DOTA-TATE)-OH and (rhTATE2.1-2.5: H-AA1-AA2-AA3-D-Dap(N-SiFAlin-N, N-Me₂-Gly)-D-Lys(trans-DOTA-TATE)-OH) with different linkers and hydrophilic modifier

SUBMITTER: Wendlinger L 

PROVIDER: S-EPMC12920295 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature