Total-body [¹⁸F]FDG-PET/CT imaging of healthy volunteers with minimal effective dose.

ABSTRACT:

Purpose

High-sensitivity, total-body (TB) positron emission tomography (PET) and computed tomography (CT) imaging systems enable substantial reduction of injected radioactivity without compromising image quality. Synthetic CT-like attenuation maps can be generated from PET data via deep learning (DL) to further minimise subject radiation exposure. We explored combining TB-PET with DL-derived attenuation maps to minimise effective dose in healthy subjects undergoing TB-PET/CT imaging with [¹⁸F]Fluorodeoxyglucose ([¹⁸F]FDG).

Methods

47 healthy Caucasians (25 F/22 M, BMI: 24 ± 3 kg/m²) underwent TB-PET/CT imaging. After 6-hour fasting, subjects received low-dose CT (1 mSv) and (109 ± 7) MBq [¹⁸F]FDG, followed by a 62-minute dynamic PET acquisiti

SUBMITTER: Ferrara D 

PROVIDER: S-EPMC12920338 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature