Molecular imaging of aortic fibroblast activation protein through ⁶⁸Ga-FAPI-PET/CT: Association with aortic dilation.

ABSTRACT:

Purpose

Aortic dilation represents an early pathological manifestation of aortic aneurysm formation. Due to the nonlinear nature of aortic expansion, relying solely on imaging-based diameter measurements is insufficient to fully assess the severity of pathological progression and the risk of rupture. ⁶⁸Ga-FAPI-PET/CT, which enables molecular imaging of fibroblast activation protein (FAP) during extracellular matrix remodeling, has been increasingly applied to evaluate cardiovascular disease. However, the application of ⁶⁸Ga-FAPI-PET/CT in aortic diameter has not yet been reported. This study aims to investigate whether aortic FAPI uptake is associated with aortic diameter/dilation.

Methods

This was a cross-sectional study including 50 oncology patients

SUBMITTER: Wang B 

PROVIDER: S-EPMC12920354 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature