Contribution of quantitative I-123-ioflupane SPECT/CT to the differential diagnosis of dementia with lewy bodies.

ABSTRACT:

Purpose

Quantification of I-123-ioflupane uptake using modern SPECT/CT improves diagnostic accuracy for disorders affecting the nigrostriatal pathway. This study assessed whether absolute and relative standardized uptake values (SUV) could distinguish dementia with Lewy bodies (DLB) from non-DLB in patients with suspected DLB and explored associations with core clinical features, including visual hallucinations (VH) and REM sleep behavior disorder (RBD).

Methods

Seventy-four patients (mean age 71.5 ± 9.26 years; 39% female) were retrospectively included. All underwent I-123-ioflupane SPECT/CT imaging with both iterative (Flash 3D) and quantitative reconstructions. SUVmax, SUVmean, and relative SUV (rSUV) values were extracted for the caudate, putamen, and striatum. Uptake me

SUBMITTER: Kurian GK 

PROVIDER: S-EPMC12920399 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature