Dataset Information
Impaired BCAA Catabolism Contributes To Acute Lung Injury By Triggering Oxidative Stress and Inflammatory Response Via the MAPK Pathway.
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ABSTRACT:
SUBMITTER: Xiong DY
PROVIDER: S-EPMC12920403 | biostudies-literature | 2026 Feb
REPOSITORIES: biostudies-literature
Publications
Impaired BCAA Catabolism Contributes To Acute Lung Injury By Triggering Oxidative Stress and Inflammatory Response Via the MAPK Pathway.
Inflammation 20260204 1
Acute lung injury (ALI) is a severe respiratory failure characterized by rapid alveolar injury, severe hypoxemia, and an uncontrolled inflammatory response. Branched-chain amino acids (BCAAs) are a group of essential amino acids, including valine, leucine, and isoleucine. Accumulating evidence shows that BCAA metabolism has long been implicated in the etiology of type 2 diabetes, myocardial ischemia/reperfusion, heart failure, cancer, and other conditions. However, the contribution of BCAA metab ...[more]