Efficacy and safety of desvenlafaxine in treating patients with major depressive disorder: a network meta-analysis.

ABSTRACT:

Background and objective

Desvenlafaxine (DVS), a commonly used serotonin-norepinephrine reuptake inhibitor (SNRI), is widely applied in the treatment of major depressive disorder (MDD). However, the efficacy and safety of different DVS dosages remain controversial. This study aims to systematically evaluate the efficacy and safety of various doses of DVS in treating MDD, providing evidence-based guidance for clinical dose selection.

Methods

A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing different doses of DVS in adult MDD patients. A Bayesian random-effects model was employed for network meta-analysis, and surface under the cumulative ranking curve (SUCRA) was used to ass

SUBMITTER: Li L 

PROVIDER: S-EPMC12920435 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature