Risk factors of necrotizing enterocolitis in very low birth weight infants: a meta-analysis.

ABSTRACT:

Background

This study aims to explore the primary risk factors for necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants through meta-analysis, providing scientific evidence for clinical prevention and treatment.

Methods

A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science databases for studies investigating risk factors for NEC in VLBW infants, covering the period from database inception to October 10, 2025. Eligible studies included case-control studies, cohort studies, and cross-sectional studies meeting the inclusion criteria. Quality assessment was performed using the NOS and AHRQ scores. Data were pooled using Stata 15 software with a random-effects model.

Results

a total of 16 research articles involving 17

SUBMITTER: Bao L 

PROVIDER: S-EPMC12920506 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature