Efficacy of blood copeptin level for the prediction of mortality of adult patients with sepsis: a meta-analysis.

ABSTRACT:

Background

Copeptin, the C-terminal fragment of provasopressin, has emerged as a potential prognostic biomarker in sepsis. However, its predictive accuracy for mortality in adult patients with sepsis remains uncertain. We conducted a systematic review and meta-analysis to evaluate the diagnostic performance of elevated blood copeptin levels for mortality prediction in this population.

Methods

We systematically searched PubMed, Embase, Web of Science, Wanfang Data, and CNKI from inception to 22 May 2025, for observational studies assessing copeptin levels at admission or within 48 h in adults with sepsis. Pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC) were calculated usi

SUBMITTER: Huang J 

PROVIDER: S-EPMC12920574 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature