The Neijiang pig T2T genome reveals domestication history and germplasm traits of Southwest Chinese local breeds.

ABSTRACT: A complete telomere-to-telomere (T2T) pig genome serves as a high-precision reference for functional genomics and structural variation studies due to its high level of completeness and minimal error rate. Here we present a comprehensive framework for genomic research aimed at the effective utilization of Neijiang pig genetic resources. The highly repetitive centromeric regions of the Neijiang pig are identified, and their characteristic centromeric landscapes are constructed using chromosomal landmark identification combined with centromeric repeat monomer localization strategies. Genome-wide association studies (GWAS) based on the T2T reference genome identify key genetic loci associated with reproductive traits, offering potential molecular targets for genetic improvement. Gene family an

SUBMITTER: Chen D 

PROVIDER: S-EPMC12920665 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature