Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis.

ABSTRACT: Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by chronic vascular inflammation and progressive aortic wall deterioration. MLKL-driven necroptosis, a highly inflammatory form of cell death, has been implicated in several cardiovascular pathologies; however, its role in AAA remains incompletely understood. Using the aortic elastase-perfusion model, we investigated the impact of necroptosis deficiency on AAA progression in necroptosis-deficient transgenic mice, including RIPK1 kinase-inactive (Ripk1^D138N/D138N), MLKL knockout (Mlkl^-/-), and MLKL phospho-deficient (Mlkl^AA) animals. Ultrasound analysis revealed that, compared to WT animals, the necroptosis-deficient animals were protected from aneurysm formation, exhibiting preser

SUBMITTER: Nemade H 

PROVIDER: S-EPMC12920694 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature