Noninvasive Brain Stimulation in Primary Progressive Aphasia with and Without Concomitant Speech and Language Therapy: Systematic Review and Meta-analysis.

ABSTRACT: Primary progressive aphasias (PPA) represent a group of neurodegenerative conditions affecting verbal communication abilities for which no effective medication is currently available. Noninvasive brain stimulation (NiBS) has been mainly explored as adjunctive therapy to conventional speech and language therapy (SLT) with promising results. The present meta-analysis of randomized-controlled trials (RCTs) aims to evaluate the efficacy of NiBS in PPA patients on a range of linguistic tasks (naming, phonemic fluency, semantic fluency). A literature search was carried out using EMBASE and PUBMED, searching for multi-session RCTs administering NiBS on PPA patients as stand-alone or with SLT. The results were not significant overall, indicating a null difference between the active and the sham co

SUBMITTER: Lomi F 

PROVIDER: S-EPMC12920721 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature