Clinical potential of [¹⁸F]FET PET in patients with circumscribed astrocytic glioma.

ABSTRACT:

Purpose

To investigate the clinical potential of O-(2-[¹⁸F]fluoroethyl)-L-tyrosine ([¹⁸F]FET) PET imaging in the management of circumscribed astrocytic gliomas (CAG), a rare glioma subtype with limited imaging data.

Methods

We retrospectively identified adult CAG patients who underwent [¹⁸F]FET PET imaging (i) before diagnosis, (ii) at suspected relapse, or (iii) for response assessment at three institutions. Maximum and mean tumor-to-brain ratios (TBR_max, TBR_mean) and metabolic tumor volumes were assessed according to the PET RANO 1.0 criteria. Diagnostic performance in differentiating treatment-related changes from tumor relapse was evaluated using ROC analysis and Fisher's exact test.

Results

We evaluated 79 [<

SUBMITTER: Werner JM 

PROVIDER: S-EPMC12920724 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature