Correlated Evolution Drives Structural Convergence of Interacting Proteins.

ABSTRACT: Understanding the relationship between protein structures and their interactions is a fundamental biological problem. Here we broadly tackle this problem by examining associations between protein structural features and interaction patterns in rodents and yeast-two highly divergent taxa from different kingdoms. In both taxa, we uncover positive correlations between intrinsic disorders of interacting proteins, consistent with a prior study showing stronger affinity between proteins with similar structures. However, closer examination reveals that these relationships are restricted to proteins involved in evolutionarily conserved interactions, or interologs. We also find that interologs generally exhibit more similar protein structures and less evolutionary structural divergence than non-int

SUBMITTER: Calix KM 

PROVIDER: S-EPMC12920738 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature