HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species.

ABSTRACT: The physiological properties of human and rodent neurons differ, yet the extent to which these differences reflect human specializations is often unclear. Compared with their rodent counterparts, human supragranular pyramidal neurons possess enriched Hyperpolarization-activated Cyclic Nucleotide-gated channel (HCN channel)-dependent intrinsic membrane properties and a related sensitivity to synaptic inputs containing delta/theta band frequencies. Here we test whether other primate species possess enriched HCN channel dependent membrane properties. We observe ubiquitous HCN1 subunit gene expression in supragranular glutamatergic neurons across New World Monkeys, Old-World Monkeys, and great apes in single nucleus RNA-sequencing datasets. Using Patch-seq recordings from acute and cultured br

SUBMITTER: Radaelli C 

PROVIDER: S-EPMC12920742 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature