Current rat models of extracorporeal life support following global ischaemia: a scoping review.

ABSTRACT:

Introduction

Small animal models are indispensable in cardiovascular research. This scoping review aims to provide an overview of contemporary rat models for extracorporeal life support (ECLS) after global ischaemia.

Material and methods

A systematic search was conducted in PubMed, Web of Science and Embase to identify studies involving rat models of global ischaemia followed by ECLS from January 2000 to December 2024. Title and abstracts were screened by two independent reviewers, and the remaining full text was included in predefined data extraction forms.

Results

A total of 79 studies met the inclusion criteria. Male Sprague Dawley rats were predominantly used (82%), with limited reporting on animal age and inconsistent use of analgesia. The majority of studies emp

SUBMITTER: Dinkelaker J 

PROVIDER: S-EPMC12920849 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature