Association of human leukocyte antigen B genotypes with COVID-19 severity in Egyptian patients.

ABSTRACT: Host genetic factors, specifically major histocompatibility complex (MHC) influence the prognosis of COVID-19 infections. It plays a central role in the body's ability to recognize and respond to pathogens, including viruses like SARS-CoV-2. This study aims to identify the significant human leukocyte antigen B (HLA-B) allele genotypes associated with severe cases among SARS-CoV-2-positive patients attending the PCR unit in The Fever Hospital-Alexandria, Egypt. This cross-sectional study was conducted from November 2022 through April 2023. Two swabs (nasopharyngeal and oropharyngeal) were collected from each patient for RT-PCR to determine the cycle threshold (Ct) value. Subsequently, 2 ml of EDTA blood was drawn from each patient for DNA extraction and HLA-B typing using the INNO-LiPA HLA-

SUBMITTER: Abdelmonem R 

PROVIDER: S-EPMC12921020 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature