Microwave ablation combined with dendritic cells enhances CD8⁺ T cell activation in rechallenged tumor mouse model.

ABSTRACT:

Objective

Microwave ablation (MWA) has shown favorable safety and efficacy in patients with non-small cell lung cancer (NSCLC). However, local recurrence remains a major concern that compromises long-term survival. Dysfunction of dendritic cells (DCs) constitutes a key immunosuppressive factor that limits effective T cell-mediated antitumor responses. To overcome this limitation, we evaluated the therapeutic potential of combining MWA with DC-based immunotherapy.

Methods

A Lewis lung carcinoma (LLC) rechallenge mouse model was established to assess the efficacy of the combination of MWA and DC therapy in preventing post-ablation tumor recurrence. The immune landscape in tumors and tumor-draining lymph nodes (TdLNs) was analyzed by flow cytometry.

Results

The combinati

SUBMITTER: Ma J 

PROVIDER: S-EPMC12921104 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature