Construction of Rough Surfaces Based on Zirconium Metal-Organic Frameworks to Enhance Photothermal and Photodynamic Therapy for Multiple Myeloma.

ABSTRACT: Nanotargeted drug delivery systems (nanotargeted DDS) have emerged as promising solutions to improve treatment precision and reduce toxicity. However, achieving efficient delivery from the bloodstream to the tumor site remains challenging due to the complex tumor microenvironment (TME). To address these issues, a novel pH-responsive surface-switching DDS, UiO@CeO₂/IR@(bPEI/HA)-A6, was designed. This system features CeO₂ immobilized on zirconium metal-organic frameworks (UiO-66-NH₂) to create a rough surface, which is then further modified with bPEI and HA-A6 polymers, facilitating its transport in the blood. After loading the photosensitizer IR-820, its photothermal conversion efficiency reached 26.8%, enabling effective photothermal and photodynamic therap

SUBMITTER: Xu M 

PROVIDER: S-EPMC12921127 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature