Evaluating Artificial Intelligence-Generated Responses to Patient Questions Regarding Orthobiologic Injections.

ABSTRACT:

Background

Patient interest in orthobiologic injections continues to grow. While modern patients are increasingly reliant on artificial intelligence (AI) large language models (LLMs) for health information, it remains unclear whether AI-generated responses regarding orthobiologics are both accurate and written at a reading level suitable for patient education.

Purpose

To assess the accuracy and readability of responses to common patient questions regarding orthobiologic injections from 3 popular AI LLMs (ChatGPT, Gemini, and Grok).

Study design

Cross-sectional Study.

Methods

Responses to 20 common patient questions regarding orthobiologic injections were recorded from ChatGPT 4o, Gemini 2.5 Flash, and Grok 3 in July 2025. Four independent reviewers (2 fellowshi

SUBMITTER: King BW 

PROVIDER: S-EPMC12921150 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature