HBP1 enhances progesterone receptor activity and IGFBP1 expression driving endometrial decidualization.

ABSTRACT: Decidualization of human endometrial stromal cells (HESCs) is one of the critical steps in the establishment of human pregnancy. Nevertheless, little is known about the molecular mechanisms underlying human decidualization. In this study, we identified high-mobility group box transcription factor 1 (HBP1) as a key player in the decidualization of HESCs. Knockdown of HBP1 expression significantly reduced the mRNA and protein expression levels of the decidualization markers insulin-like growth factor-binding protein 1 (IGFBP1) and forkhead box O1 (FOXO1). Although progesterone receptor (PGR) expression did not significantly change, the expression levels of PGR-regulated target molecules decreased. Furthermore, ChIP-Seq and RNA-Seq analyses revealed that HBP1 directly transcriptionally regula

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12921247 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature