The DNA methylation landscape of naturally short-lived killifish.

ABSTRACT: Annual killifish of the genus Nothobranchius are naturally short-lived vertebrates that exhibit a wide range of aging characteristics typically observed in mammals. Here, we provide the first comprehensive whole-genome methylation map for two species, revealing local age-related as well as tissue-specific dynamics in the DNA methylome. Our maps and results support the annual killifish as a model organism and further highlight its value for studying aging including possible health status predictions in vertebrates.

SUBMITTER: Steiger M 

PROVIDER: S-EPMC12921331 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature