Integrated multi-omics analysis of dampness-heat gout reveals diagnostic biomarkers and therapeutic targets.

ABSTRACT: Damp-heat gout (DHG) is a highly certified type of disease integrated with syndrome in TCM. The ambiguity of its pathomechanism and the lack of quantifiable indicators limit its clinical accurate diagnosis and treatment. This study aimed to elucidate the pathological mechanism of DHG and establish a symptom-centered diagnostic and therapeutic model. We recruited 136 participants, comprising healthy controls (HCs) and DHG patients. Serum metabolomics and proteomics analyses were performed to screen common pathways. Based on the biological significance of these common pathways, a symptom-pathway correlation network was constructed to clarify the pathological mechanisms driving DHG occurrence and progression. Enrichment scores and correlations with key DHG symptoms were used to identify criti

SUBMITTER: Yang L 

PROVIDER: S-EPMC12921442 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature